Herpes Might Cause Alzheimer's
By Robin Lloyd
Senior Editor
03 January 2007

New research supports growing concerns that herpes plays a role in the development of Alzheimer’s disease, the most common form of dementia.

The latest work, announced today, shows a link between a gene and herpes simplex 1, or HSV. The form of the ApoE gene called ApoE-4 is the leading known risk factor for Alzheimer’s. And HSV is the form of herpes that causes cold sores around the mouth. More than 80 percent of Americans are infected with HSV.

The researchers, at the University of Rochester Medical Center, found that ApoE-4 effectively puts out a welcome mat for the herpes virus, allowing it to be more active in the brain.

“The data suggest that ApoE-4 may support the ability of HSV to be a more virulent pathogen,” said Howard Federoff, lead author of the research published online in the journal Neurobiology of Aging. the rest