Damaged heart could be coaxed into mending itself, claim scientists

A broken heart could soon be able to mend itself after scientists discover a way of converting ordinary tissue into beating muscle cells.
By Richard Alleyne, Science Correspondent
05 Aug 2010

In as little as five years, researchers hope to be able to coax the heart into regenerating itself, repairing the damage caused by cardiac arrests and old age.

The revolutionary treatment could be possible after scientists discovered a technique for turning ordinary connective tissue into muscle cells inside the heart.

It works in a similar way to stem cells but instead of the new cells being grown outside the body and then injected back in, the technique simply makes the cells switch at the point where they are needed.

Around 700,000 people in Britain suffer from heart failure because it has virtually no ability to repair itself after an attack.

The main problem is that when beating muscles cells – known as cardiomyocytes – die during an attack there is no way to reactivate them and the surrounding connective tissue – known as fibroblasts – cannot take over their role.

Now Professor Deepak Srivastava at the Gladstone Institute, University of California, and his team have discovered a way of reprogramming fibroblasts into cardiomyocytes. the rest